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Adverse Effects:

Cardiovascular Effects

Cardiovascular finding

1) HYPOTENSION has been reported occasionally following oral or parenteral thiocolchicoside [7]; (Prod Info Muscoril(R), 1998). However, causality has not been clearly established.

Dermatologic Effects

Dermatological finding

1) In a pharmacoepidemiological study involving hospitalized patients (n=5212) treated with thiocolchicoside (mostly intramuscularly), cutaneous erythema was reported in 0.13% and dermatitis in 0.04% [7].
2) CONTACT DERMATITIS and photocontact allergy have been reported rarely after topical application [11][12].

Gastrointestinal Effects

Gastrointestinal tract finding

1) In a pharmacoepidemiological study involving hospitalized patients (n=5212) treated with thiocolchicoside (mostly intramuscularly), GASTRALGIA was reported in 0.4%, DIARRHEA in 0.15%, NAUSEA 0.07%, and pyrosis in 0.04% [7]. These symptoms have been reported in a small number of cases in other studies [8][9][10].

Neurologic Effects

Central nervous system finding

1) AGITATION and DROWSINESS have been occasionally reported after intramuscular administration of thiocolchicoside (Prod Info Muscoril(R), 1998).
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